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Drug that causes an adverse reaction to alcohol
A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea , vomiting , flushing , dizziness , throbbing headache , chest and abdominal discomfort , and general hangover -like symptoms among others.[1] [2] acetaldehyde , a major but toxic metabolite of alcohol formed by the enzyme alcohol dehydrogenase .[1] [2] disulfiram-like reaction alcohol intolerance , and acetaldehyde syndrome .[3]
The prototypical drug of this group is disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor , preventing the metabolism of acetaldehyde into acetic acid , and is used in the treatment of alcoholism .[1] [2] drug interactions and side effects .[1] [2] enzyme , and instead act via other, poorly elucidated mechanisms .
Unlike acetaldehyde dehydrogenase inhibitors and other disulfiram-like drugs, alcohol dehydrogenase inhibitors such as fomepizole (brand name Antizol) inhibit the metabolism of alcohol into acetaldehyde, thereby increasing and extending the effects of alcohol and reducing its toxicity.[4] [4] antidote against methanol and ethylene glycol poisoning .[4]
List of agents [ edit ]
Intended [ edit ]
Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an intended effect include:[5]
Unintended [ edit ]
Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include:[6] [1] [7]
Cephalosporins , but only these with a methylthiotetrazole side chain or a methylthiodioxotriazine ring; thought to be due to common N metabolite , which is similar in structure to disulfiram.[8] cefamandole , cefmenoxime , cefmetazole , cefonicid , cefoperazone , cefotetan , ceftriaxone , and latamoxef (moxalactam) .[9] [10]
Chloral hydrate
Chloramphenicol
Ethacrynic acid
Griseofulvin (weak evidence)[8]
Hydrazines
Ketoconazole (weak evidence)[8]
Macrolide immunosuppressants such as pimecrolimus and tacrolimus
Mepacrine (quinacrine)
Nilutamide
Nitrovasodilators (nitrates) such as nitroglycerin
Nitroimidazoles such as benznidazole , metronidazole (disproven),[8] ornidazole .
Pargyline
Phenacetin
Phentolamine
Phenylbutazone
Propranolol
Sulfiram
Sulfonamides : sulfamethoxazole likely safe[8]
Sulfonylureas , specifically the first generation:[8] chlorpropamide , glibenclamide (glyburide) , and tolbutamide
Tolazoline
A number of drugs do not cause disulfiram-like reactions, but have other unintended interactions with alcoholic drinks. For example, alcohol interferes with the efficacy of erythromycin . Patients on linezolid and tedizolid may be sensitive to the tyramine present in tap beers and red wine.[8]
Antibiotics [ edit ]
Antibiotics such as metronidazole , tinidazole , cephamandole , latamoxef , cefoperazone , cefmenoxime , and furazolidone , cause a disulfiram -like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde dehydrogenase , which may result in vomiting, nausea, and shortness of breath.[11] erythromycin succinate may be reduced by alcohol consumption.[12] [13]
Natural [ edit ]
Natural compounds and species which have been found to cause disulfiram-like reactions upon ingestion of alcohol include:[14] [15]
List of agents previously thought to cause disulfiram-like reactions [ edit ]
See also [ edit ]
References [ edit ]
^ Mutalik, M., & Sanghavi, D. (2014). Review of Drug Interactions: A Comprehensive Update .
^ a b c McMartin K, Jacobsen D, Hovda KE (2016). "Antidotes for poisoning by alcohols that form toxic metabolites" . Br J Clin Pharmacol . 81 3 ): 505–15. doi :10.1111/bcp.12824 . PMC 4767193 PMID 26551875 .
^ Helmut K. Seitz; B. Kommerell (6 December 2012). Alcohol Related Diseases in Gastroenterology ISBN 978-3-642-70048-4
^ Amitava Dasgupta (17 October 2016). Alcohol, Drugs, Genes and the Clinical Laboratory: An Overview for Healthcare and Safety Professionals ISBN 978-0-12-809334-4
^ Reginald Smart (22 November 2013). Research Advances in Alcohol and Drug Problems ISBN 978-1-4613-3626-6
^ a b c d e f g h i j k Mergenhagen, Kari A.; Wattengel, Bethany A.; Skelly, Megan K.; Clark, Collin M.; Russo, Thomas A. (21 February 2020). "Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions" . Antimicrobial Agents and Chemotherapy . 64 3 ). doi :10.1128/aac.02167-19 . PMC 7038249
^ Kitson TM (1987). "The effect of cephalosporin antibiotics on alcohol metabolism: a review". Alcohol . 4 3 ): 143–8. doi :10.1016/0741-8329(87 )90035-8 . PMID 3593530 .
^ Lewis R. Goldfrank (2006). Goldfrank's Toxicologic Emergencies ISBN 978-0-07-147914-1
^ "Can I drink alcohol while taking antibiotics?" . NHS Direct (UK electronic health service). Archived from the original on 24 October 2010. Retrieved 17 February 2008 .
^ Stockley IH (2002). Stockley's Drug Interactions (6th ed.). London: Pharmaceutical Press. [page needed
^ "Antibiotics FAQ" . McGill University, Canada. Archived from the original on 16 February 2008. Retrieved 17 February 2008 .
^ Joseph F. Ammirati (1985). Poisonous Mushrooms of the Northern United States and Canada ISBN 978-0-8166-1407-3
^ Barry H. Rumack ; David G. Spoerke (27 September 1994). Handbook of Mushroom Poisoning: Diagnosis and Treatment ISBN 978-0-8493-0194-0
^ "Herbal Approaches to Alcohol Dependence: Evidence and Risks" . Pharmacy Times . 7 December 2016.
^ Workowski, Kimberly A; Bachmann, Laura H; Chan, Philip A; Johnston, Christine M; Muzny, Christina A; Park, Ina; Reno, Hilary; Zenilman, Jonathan M; Bolan, Gail A (2021). "Sexually Transmitted Infections Treatment Guidelines, 2021" . MMWR. Recommendations and Reports . 70 4 ): 1–187. doi :10.15585/mmwr.rr7004a1 . PMC 8344968 PMID 34292926 .
^ Fjeld, Hilde; Raknes, Guttorm (16 September 2014). "Er det virkelig farlig å kombinere metronidazol og alkohol?" . Tidsskrift for den Norske Legeforening . 134 (17 ): 1661–1663. doi :10.4045/tidsskr.14.0081 ISSN 0029-2001 . PMID 25223673 . Retrieved 22 February 2022 .
External links [ edit ]
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Disulfiram-like_drug&oldid=1226305916 " C a t e g o r i e s : ● A l c o h o l ● A l c o h o l a b u s e ● A l c o h o l a n d h e a l t h ● D i s u l f i r a m - l i k e d r u g s ● S u b s t a n c e - r e l a t e d d i s o r d e r s H i d d e n c a t e g o r i e s : ● W i k i p e d i a a r t i c l e s n e e d i n g p a g e n u m b e r c i t a t i o n s f r o m D e c e m b e r 2 0 1 3 ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● U s e d m y d a t e s f r o m O c t o b e r 2 0 2 2 ● C o m m o n s c a t e g o r y l i n k i s l o c a l l y d e f i n e d
● T h i s p a g e w a s l a s t e d i t e d o n 2 9 M a y 2 0 2 4 , a t 2 0 : 1 6 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
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