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Clinical data | |
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MedlinePlus | a682088 |
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ECHA InfoCard | 100.008.275 ![]() |
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Formula | C11H13N |
Molar mass | 159.232 g·mol−1 |
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Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 11.52 nM and for MAO-B is 8.20 nM)[1][2] It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine.[3]: 146 [4]: 60 [5][6] By 2007 the drug was discontinued[7] and as of 2014 there were no generic versions available in the US.[8] In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I2 imidazoline receptor (anallosteric site on the MAO enzyme).[9]
Pargyline is promoted only for the treatment of hypertension, and not for depression.
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Sympatholytics (antagonize α-adrenergic vasoconstriction) |
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Non-specific |
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Phenethylamines (dopamine, epinephrine, norepinephrine) |
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Tryptamines (serotonin, melatonin) |
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Histamine |
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins |
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