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Ephrin A4

Protein-coding gene in the species Homo sapiens

EFNA4
Identifiers
Aliases	EFNA4, EFL4, EPLG4, LERK4, ephrin A4, LERK-4
External IDs	OMIM: 601380; MGI: 106643; HomoloGene: 3830; GeneCards: EFNA4; OMA:EFNA4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 155,063,737 bp[1] End 155,069,553 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.07 cM Start 89,240,697 bp[2] End 89,245,335 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad skin of leg skin of abdomen mucosa of transverse colon right adrenal cortex rectum left adrenal gland minor salivary glands left adrenal cortex gingival epithelium Top expressed in maxillary prominence mandibular prominence lip otic vesicle ventricular zone superior surface of tongue genital tubercle embryo hand saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane-ephrin receptor activity protein binding ephrin receptor binding Cellular component anchored component of membrane plasma membrane integral component of plasma membrane membrane extracellular region intrinsic component of plasma membrane Biological process cell-cell signaling ephrin receptor signaling pathway axon guidance osteoclast differentiation bone remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1945 13639 Ensembl ENSG00000243364 ENSMUSG00000028040 UniProt P52798 O08542 RefSeq (mRNA) NM_182690 NM_005227 NM_182689 NM_007910 RefSeq (protein) NP_005218 NP_872631 NP_872632 NP_031936 Location (UCSC) Chr 1: 155.06 – 155.07 Mb Chr 3: 89.24 – 89.25 Mb PubMed search [3] [4]
Wikidata
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Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.^[5][6]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.^[6]

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