InChI=1S/C21H27N3O/c1-4-23(5-2)21(25)15-10-17-16-8-7-9-18-20(16)14(12-22-18)11-19(17)24(6-3)13-15/h7-10,12,15,19,22H,4-6,11,13H2,1-3H3/t15-,19-/m1/s1^Y

Key:MYNOUXJLOHVSMQ-DNVCBOLYSA-N^Y

^NY (what is this?) (verify)

ETH-LAD, 6-ethyl-6-nor-lysergic acid diethylamide is an analogue of LSD. Its human psychopharmacology was first described by Alexander Shulgin in the book TiHKAL. ETH-LAD is a psychedelic drug similar to LSD, and is slightly more potent than LSD itself,^[2] with an active dose reported at between 20 and 150 micrograms. ETH-LAD has subtly different effects to LSD, described as less demanding. The true tryptamine counterpart of ETH-LAD is MET, a simplified version of this structure.

Legality[edit]

On June 10, 2014, the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that ETH-LAD be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.^[3] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015.^[4]

ETH-LAD is illegal in Switzerland as of December 2015.^[5]

References[edit]

^ "Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants". www.legifrance.gouv.fr (in French). 20 May 2021.

^ Hoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry. 28 (9): 1252–5. doi:10.1021/jm00147a022. PMID 4032428.

^ Advisory Council on the Misuse of Drugs (ACMD) (10 June 2014). "Update of the Generic Definition for Tryptamines" (PDF). UK Home Office. p. 12. Retrieved 10 June 2014.

^ "The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014".

^ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien". Der Bundesrat.

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Unknown/unsorted: Ergolines (e.g., 2-Br-LSD (BOL-148), bromocriptine, lergotrile, pergolide)

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5-HT₇

Agonists: 8-OH-DPAT

AS-19

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Butaclamol

DR-4485

EGIS-12,233

Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)

JNJ-18038683

Ketanserin

LY-215,840

Metitepine (methiothepin)

Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)

Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)

Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)

Vortioxetine

Unknown/unsorted: Ergolines (e.g., lisuride, pergolide)

Piperazines (e.g., naphthylpiperazine)

See also: Receptor/signaling modulators

Adrenergics

Dopaminergics

Melatonergics

Monoamine reuptake inhibitors and releasing agents

Monoamine metabolism modulators

Monoamine neurotoxins

Ergolines

Lysergic acid
derivatives

2-Bromo-LSD (BOL-148)

Dihydroergometrine (Dihydroergonovine, Dihydroergobasine)

Dihydroergosine

Dihydroergotamine

Epicriptine

Ergine (LSA; LA-111; Lysergamide)

Ergocornine

Ergocristine

Ergocryptine

Ergoloid (Dihydroergotoxine)

Ergometrine (Ergonovine, Ergobasine)

LSH

Lysergic acid methyl ester

Psychedelic
lysergamides

1B-LSD

Diallyllysergamide (DAL)

Dimethyllysergamide (DAM-57)

LSD

LSH

Lysergic Acid 2-Butylamide

Lysergic Acid 2,4-Dimethylazetidide

Lysergic Acid 3-Pentylamide

Lysergic acid cyclobutylamide

Lysergic acid cyclopentylamide

Methylergometrine (Methylergonovine, Methylergobasine)

Clavines

9-Deacetoxyfumigaclavine C

Other
ergolines

Acetergamine

Natural
sources

Achnatherum robustum (Sleepy Grass)

Claviceps spp. (Ergot)

Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)

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Contents

ETH-LAD

Legality[edit]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]