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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | ENO2, HEL-S-279, NSE, Enolase 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 131360; MGI: 95394; HomoloGene: 74414; GeneCards: ENO2; OMA:ENO2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[5][6] Gamma-enolase is a phosphopyruvate hydratase.
Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[5]
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.[7]
PDB gallery
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1te6: Crystal Structure of Human Neuron Specific Enolase at 1.8 angstrom
2akm: Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex
2akz: Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex
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4.2.1: Hydro-Lyases |
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4.2.2: Acting on polysaccharides |
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4.2.3: Acting on phosphates |
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4.2.99: Other |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Blood |
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Endocrine |
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Nervous system |
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General histology |
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Musculoskeletal |
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