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Etoxeridine

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Etoxeridine
Clinical data

Other names	Etoxeridine, Carbetidine, Atenos
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs)^[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) UK: Class A US: Schedule I
Identifiers
IUPAC name Ethyl 1-[2-(2-hydroxyethoxy)ethyl]-4-phenylpiperidine-4-carboxylate
CAS Number	469-82-9^Y
PubChem CID	61122
DrugBank	DB01505^Y
ChemSpider	55070^Y
UNII	RHW35E1G7E
KEGG	D12680^Y
ChEMBL	ChEMBL2104254
CompTox Dashboard (EPA)	DTXSID30196980
ECHA InfoCard	100.006.750
Chemical and physical data
Formula	C₁₈H₂₇NO₄
Molar mass	321.417 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1(CCN(CC1)CCOCCO)(C(=O)OCC)C2=CC=CC=C2
InChI InChI=1S/C18H27NO4/c1-2-23-17(21)18(16-6-4-3-5-7-16)8-10-19(11-9-18)12-14-22-15-13-20/h3-7,20H,2,8-15H2,1H3^Y Key:KJTKYGFGPQSRRA-UHFFFAOYSA-N^Y
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Etoxeridine (Carbetidine, Atenos) is a 4-phenyl piperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine).

Etoxeridine was developed in the 1950s^[2] and investigated for use in surgical anesthesia, however it was never commercialized and is not currently used in medicine.^[3]^[4]^[5] As with other opioids which were not in clinical use during the drafting of the Controlled Substances Act, it is categorized as a Schedule I narcotic.

References[edit]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

^ BE 558883

^ Merlevede E, Levis S (1958). "Pharmacological study of carbetidine, a new synthetic analgesic". Archives Internationales de Pharmacodynamie et de Thérapie (in French). 115 (1–2): 213–232. PMID 13545901.

^ Sironi PG (1959). "Brief note on a new synthetic analgesic: carbetidine hydrochloride". Minerva Anestesiologica (in Italian). 25 (6): 251–254. PMID 13674097.