Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptideorCD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene.
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds.[5] The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury,[6] and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis.[7] This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard–Soulier syndromes and platelet-type von Willebrand disease.[8]
GP1BA has been shown to interact with YWHAZ[9][10][11] and FLNB.[12]
PDB gallery
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1gwb: STRUCTURE OF GLYCOPROTEIN 1B
1m0z: Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha
1m10: Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain
1ook: Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin
1p8v: CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A
1p9a: Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 1.7 Angstrom Resolution
1qyy: Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution
1sq0: Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution
1u0n: The ternary von Willebrand Factor A1-glycoprotein Ibalpha-botrocetin complex
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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