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(Top) 1 References

GPR88

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GPR88

Identifiers

GPR88, STRG, COCPMR, G protein-coupled receptor 88

External IDs

OMIM: 607468; MGI: 1927653; HomoloGene: 11104; GeneCards: GPR88; OMA:GPR88 - orthologs

Gene location (Human)

Chromosome 1 (human)^[1]

1p21.2

Start

100,538,139 bp^[1]

End

100,542,021 bp^[1]

Gene location (Mouse)

Chromosome 3 (mouse)^[2]

3|3 G1

Start

116,043,303 bp^[2]

End

116,047,152 bp^[2]

RNA expression pattern

Mouse (ortholog)

Top expressed in

external globus pallidus

putamen

caudate nucleus

nucleus accumbens

endothelial cell

entorhinal cortex

middle temporal gyrus

prefrontal cortex

right lobe of liver

dorsolateral prefrontal cortex

Top expressed in

olfactory tubercle

globus pallidus

nucleus accumbens

superior frontal gyrus

lateral septal nucleus

piriform cortex

lumbar subsegment of spinal cord

temporal lobe

barrel cortex

primary visual cortex

More reference expression data

More reference expression data

Molecular function

signal transducer activity

cytoskeletal motor activity

G protein-coupled receptor activity

G protein-coupled photoreceptor activity

Cellular component

integral component of membrane

plasma membrane

cellular component

integral component of plasma membrane

Biological process

locomotory behavior

neuromuscular process controlling balance

neuronal action potential

signal transduction

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

chemical synaptic transmission

feeding behavior

phototransduction

detection of visible light

cellular response to light stimulus

Sources:Amigo / QuickGO

Species

Human

Mouse

ENSG00000181656

ENSMUSG00000068696

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1: 100.54 – 100.54 Mb

Chr 3: 116.04 – 116.05 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene.

References[edit]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Mizushima K, Miyamoto Y, Tsukahara F, et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum". Genomics. 69 (3): 314–21. doi:10.1006/geno.2000.6340. PMID 11056049.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Van Waes V, Tseng K, Steiner H (2011). "GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation". Basal Ganglia. 1 (2): 83–89. doi:10.1016/j.baga.2011.04.001. PMC 3144573. PMID 21804954.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

α1 (A

B

D)

B

C)

Adenosine (A1

A3)

2

4

5

6

8

9

14)

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

B

C)

5-HT (4

6

7)

Other

Acetylcholine (M1

M5)

D1
D2
D3
D4
D5

H1
H2
H3
H4

1C)

2

5

6

8

9)

Metabolites and
signaling molecules

CysLT (1

2)

1

2

DP (1
2), EP (1
2
3
4), FP

Other

Bile acid

Cannabinoid (CB1

CB2, GPR (18

119))

Free fatty acid (1

2

3

4)

Hydroxycarboxylic acids

1
2
3

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Sphingosine-1-phosphate (1

2

3

4

5)

Peptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

2)

Other

Anaphylatoxin (C3a

C5a (1

2))

2)

Cholecystokinin (A

B)

A
B

Formyl peptide (1

2

3)

2

3)

Gonadotropin-releasing hormone (1

2)

Luteinizing hormone/choriogonadotropin

D

E

F

G

X4)

Melanocortin (1

2

3

4

5)

2)

Nociceptin & Zeta, but not Sigma)

2)

Prokineticin (1

2)

Prolactin-releasing peptide

2

3

4)

Somatostatin (1

2

3

4

5)

2

3)

Thyrotropin-releasing hormone

Vasopressin (1A

2)

Miscellaneous

Taste, bitter

TAS2R
- 1

3

4

5

7

8

9

Vomeronasal receptor type 1

GPR (1

3

4

6

Other

Adrenomedullin

4

5

Protease-activated (1

2

3

4)

2

3)

Class B: Secretin-like

ADGRB
- Brain-specific angiogenesis inhibitor
  - 1

2

3

ADGRC

Cadherin
- 1
- 2
- 3

ADGRE

EMR
- 1
- 2
- 3
CD97

ADGRG

1
2
3
4
5
6
7

ADGRL

Latrophilin
- 1
- 2
- 3
ELTD1

GPR (56

Other

Calcitonin

Corticotropin-releasing hormone (1

2)

Growth-hormone-releasing hormone

Methuselah-like proteins

Parathyroid hormone (1

2)

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet

TAS1R
- 1

2

3

Vomeronasal receptor, type 2

Other

Calcium-sensing receptor

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

2

3

4)

Class F: Frizzled & Smoothened

Frizzled

Frizzled (1

2

3

4

5

6

7

8

9

10)

Smoothened

Smoothened

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^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181656 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068696 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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