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● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
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P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 R e f e r e n c e s
T o g g l e t h e t a b l e o f c o n t e n t s
4 - H y d r o x y - 3 - m e t h y l b u t - 2 - e n y l d i p h o s p h a t e r e d u c t a s e
5 l a n g u a g e s
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E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
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P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
( R e d i r e c t e d f r o m H M B - P P r e d u c t a s e )
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2 , isopentenyl-diphosphate:NADP+ oxidoreductase , LytB , (E )-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase , HMBPP reductase , IspH , LytB/IspH ) is an enzyme in the non-mevalonate pathway . It acts upon (E )-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (or "HMB-PP").[1] [2] [3] [4] [5] [6]
(1 ) isopentenyl diphosphate + NAD(P )+ + H2 O
⇌
{\displaystyle \rightleftharpoons }
E )-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P )H + H+
(2 ) dimethylallyl diphosphate + NAD(P )+ + H2 O
⇌
{\displaystyle \rightleftharpoons }
E )-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P )H + H+
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase is an iron -sulfur protein that contains either a [3Fe-4S] or a [4Fe-4S] cluster.
References
[ edit ]
^ Charon, L.; Pale-Grosdemange, C.; Rohmer, M. (1999). "On the reduction steps in the mevalonate independent 2-C D Zymomonas mobilis ". Tetrahedron Lett . 40 40 ): 7231–7234. doi :10.1016/s0040-4039(99 )01531-2 .
^ Röhrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F, Balconi E, Aliverti A, Zanetti G, Köhler U, Pfeiffer M, Beck E, Jomaa H, Wiesner J (November 2005). "Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum" . FEBS Letters . 579 (28 ): 6433–8. doi :10.1016/j.febslet.2005.10.037 PMID 16289098 .
^ Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia Estrabot A, Rodríguez-Concepción M, Boronat A, Marquet A, Rohmer M (April 2003). "Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E )-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein" . FEBS Letters . 541 (1–3): 115–20. doi :10.1016/s0014-5793(03 )00317-x PMID 12706830 .
^ Gräwert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S, Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C, Arigoni D, Bacher A, Eisenreich W, Rohdich F (October 2004). "IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis". Journal of the American Chemical Society . 126 (40 ): 12847–55. doi :10.1021/ja0471727 . PMID 15469281 .
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Regulation
Classification
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=4-Hydroxy-3-methylbut-2-enyl_diphosphate_reductase&oldid=1172336359 " C a t e g o r i e s : ● E C 1 . 1 7 . 1 ● E n z y m e s t u b s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 6 A u g u s t 2 0 2 3 , a t 1 2 : 4 1 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
