Contents

IFNK

Protein-coding gene in the species Homo sapiens

IFNK
Identifiers
Aliases	IFNK, IFNT1, INFE1, interferon kappa
External IDs	OMIM: 615326; MGI: 2683287; HomoloGene: 36384; GeneCards: IFNK; OMA:IFNK - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 27,524,290 bp[1] End 27,526,498 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 35,152,056 bp[2] End 35,154,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Achilles tendon corpus callosum epithelium of colon monocyte skeletal muscle tissue blood muscle of thigh cervix respiratory system Top expressed in blastocyst embryo morula placenta tail of embryo yolk sac uterus liver stomach genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response response to virus natural killer cell activation B cell proliferation regulation of transcription, DNA-templated humoral immune response adaptive immune response positive regulation of peptidyl-serine phosphorylation of STAT protein defense response to virus response to exogenous dsRNA negative regulation of cell population proliferation cytokine-mediated signaling pathway positive regulation of innate immune response T cell activation involved in immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56832 387510 Ensembl ENSG00000147896 ENSMUSG00000042993 UniProt Q9P0W0 Q7TSL0 RefSeq (mRNA) NM_020124 NM_199157 RefSeq (protein) NP_064509 NP_954608 Location (UCSC) Chr 9: 27.52 – 27.53 Mb Chr 4: 35.15 – 35.15 Mb PubMed search [3] [4]
Wikidata
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Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.^[5][6][7]

IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.^[5]

3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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