chemokine (C-C motif) ligand 23 | |||||||
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Identifiers | |||||||
Symbol | CCL23 | ||||||
Alt. symbols | SCYA23, Ckb-8, MPIF-1, MIP-3, CKb8 | ||||||
NCBI gene | 6368 | ||||||
HGNC | 10622 | ||||||
OMIM | 602494 | ||||||
PDB | 1G91 | ||||||
RefSeq | NM_005064 | ||||||
UniProt | P55773 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.[1] It is also expressed in some cell linesofmyeloid origin. CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells.[1] The gene for CCL23 is located on human chromosome 17 in a locus containing several other CC chemokines. CCL23 is a ligand for the chemokine receptor CCR1.[2]
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