Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[5][6]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[5]
Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Chemokine receptor (GPCRs) |
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TNF receptor |
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JAK-STAT |
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Ig superfamily |
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IL 17 family |
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Enzyme-linked receptor |
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IL-1 |
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IL-2 |
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IL-3 |
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IL-4 |
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IL-5 |
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IL-6 |
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IL-7 |
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IL-8 |
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IL-9 |
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IL-10 |
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IL-11 |
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IL-12 |
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IL-13 |
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IL-15 |
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IL-17 |
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IL-18 |
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IL-20 |
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IL-21 |
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IL-22 |
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IL-23 |
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IL-27 |
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IL-28 |
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IL-31 |
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IL1RL1 |
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IL1RL2 |
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Others |
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