This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is L-serine ammonia-lyase (pyruvate-forming). Other names in common use include serine deaminase, L-hydroxyaminoacid dehydratase, L-serine deaminase, L-serine dehydratase, and L-serine hydro-lyase (deaminating). This enzyme participates in glycine, serine, threonine and cysteine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1P5J, 1PWE, 1PWH, and 2IQQ.

References[edit]

Ramos F, Wiame JM (1982). "Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae". Eur. J. Biochem. 123 (3): 571–6. doi:10.1111/j.1432-1033.1982.tb06570.x. PMID 7042346.
Simon D, Hoshino J, Kroger H (1973). "L-serine dehydratase from rat liver. Purification and some properties". Biochim. Biophys. Acta. 321 (1): 361–8. doi:10.1016/0005-2744(73)90091-0. PMID 4750769.
Suda M, Nakagawa H (1971). L-Serine dehydratase (rat liver). Methods Enzymol. Vol. 17B. pp. 346–351. doi:10.1016/0076-6879(71)17060-7.
Sagers RD, Carter JE (1971). L-Serine dehydratase (Clostridium acidiurica). Methods Enzymol. Vol. 17B. pp. 351–356. doi:10.1016/0076-6879(71)17061-9.
Robinson WG, Labow R (1971). L-Serine dehydratase (Escherichia coli). Methods Enzymol. Vol. 17B. pp. 356–360. doi:10.1016/0076-6879(71)17062-0.

Carbon–nitrogen lyases (EC 4.3)

4.3.1: ammonia-lyases

4.3.2: amidine-lyases

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

This enzyme-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=L-serine_ammonia-lyase&oldid=1230294562" Categories: ●EC 4.3.1 ●Pyridoxal phosphate enzymes ●Enzymes of known structure ●Enzyme stubs Hidden category: ●All stub articles ●This page was last edited on 21 June 2024, at 21:47 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view