Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 See also  




2 References  













LP-44






●Español
 ●فارسی
 ●Српски / srpski
 ●Srpskohrvatski / српскохрватски
 ●Türkçe
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  

LP-44
Identifiers

  • 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide

CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC27H37N3OS
Molar mass451.67 g·mol−1
3D model (JSmol)

  • c3cccc2c3CCCC2NC(=O)CCCCCN(CC4)CCN4c1ccccc1SC

  • InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) ☒N

  • Key:JNBBJUHCODFLEG-UHFFFAOYSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor. While LP-44 is less selective than the related compound LP-12, it has been more widely used in research and has been used to show the complex role of 5-HT7 receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.[1][2][3][4]

See also[edit]

References[edit]

  1. ^ Monti JM, Leopoldo M, Jantos H (August 2008). "The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat". Behavioural Brain Research. 191 (2): 184–9. doi:10.1016/j.bbr.2008.03.025. PMID 18466985. S2CID 14310667.
  • ^ Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO (May 2011). "Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway". Neuroscience. 182: 71–81. doi:10.1016/j.neuroscience.2011.02.042. PMID 21371532. S2CID 1452141.
  • ^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.
  • ^ Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L (April 2011). "5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission". Hippocampus. 22 (4): 790–801. doi:10.1002/hipo.20940. PMID 21538661. S2CID 718851.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=LP-44&oldid=1108873485"
    Categories: 
    ●5-HT7 agonists
     ●1-Aminotetralins
     ●Phenylpiperazines
     Hidden categories: 
    ●Articles with short description
     ●Short description matches Wikidata
     ●Articles with changed ChemSpider identifier
     ●Articles with changed InChI identifier
     ●Articles without EBI source
     ●Chemical pages without DrugBank identifier
     ●Articles without KEGG source
     ●Drugs missing an ATC code
     ●Drugs with no legal status
     ●Drugboxes which contain changes to verified fields
      


    ●This page was last edited on 6 September 2022, at 18:38 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki