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(Top) 1 Function 2 References 3 Further reading

MYH4

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MYH4

Identifiers

Aliases

MYH4, MYH2B, MyHC-2B, MyHC-IIb, myosin, heavy chain 4, skeletal muscle, myosin heavy chain 4

External IDs

OMIM: 160742; MGI: 1339713; HomoloGene: 123880; GeneCards: MYH4; OMA:MYH4 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.1	Start	10,443,290 bp^[1]
Band	17p13.1	End	10,469,559 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 B3\|11 40.59 cM	Start	67,128,855 bp^[2]
Band	11 B3\|11 40.59 cM	End	67,151,272 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Skeletal muscle tissue of rectus abdominis

vastus lateralis muscle

biceps brachii

Skeletal muscle tissue of biceps brachii

deltoid muscle

muscle of thigh

testicle

thoracic diaphragm

tibialis anterior muscle

gastrocnemius muscle

Top expressed in

extensor digitorum longus muscle

tibialis anterior muscle

vastus lateralis muscle

medial head of gastrocnemius muscle

sternocleidomastoid muscle

plantaris muscle

triceps brachii muscle

digastric muscle

temporal muscle

body of femur

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding actin binding microfilament motor activity double-stranded RNA binding ATPase activity cytoskeletal motor activity ATP binding calmodulin binding actin filament binding microtubule motor activity microtubule binding
Cellular component	cytoplasm myosin filament muscle myosin complex myofibril sarcomere myosin complex
Biological process	ATP metabolic process muscle contraction actin filament-based movement muscle filament sliding microtubule-based movement response to activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4622


17884

Ensembl


ENSG00000264424


ENSMUSG00000057003

UniProt


Q9Y623


Q5SX39

RefSeq (mRNA)


NM_017533


NM_010855

RefSeq (protein)


NP_060003


NP_034985

Location (UCSC)

Chr 17: 10.44 – 10.47 Mb

Chr 11: 67.13 – 67.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.^[5]

Function[edit]

MYH4 is a gene that encodes a sarcomeric myosin.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000264424 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057003 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272. S2CID 7405468.

Further reading[edit]

Sant'ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). "New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types". J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402. S2CID 20954615.

Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.

Barton PJ, Buckingham ME (1985). "The myosin alkali light chain proteins and their genes". Biochem. J. 231 (2): 249–61. doi:10.1042/bj2310249. PMC 1152739. PMID 3904738.

Horton MJ, Brandon CA, Morris TJ, et al. (2001). "Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres". Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMC 3848045. PMID 11543711.

Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.

Larsson L, Moss RL (1993). "Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles". J. Physiol. 472: 595–614. doi:10.1113/jphysiol.1993.sp019964. PMC 1160504. PMID 8145163.

Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). "Mts1 regulates the assembly of nonmuscle myosin-IIA". Biochemistry. 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.

Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.

Ford HL, Silver DL, Kachar B, et al. (1997). "Effect of Mts1 on the structure and activity of nonmuscle myosin II". Biochemistry. 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.

Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

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