Contents

Tropomodulin 2

Protein-coding gene in the species Homo sapiens

TMOD2
Identifiers
Aliases	TMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDs	OMIM: 602928; MGI: 1355335; HomoloGene: 22817; GeneCards: TMOD2; OMA:TMOD2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,751,597 bp[1] End 51,816,363 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.31 cM Start 75,472,903 bp[2] End 75,518,607 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus lateral nuclear group of thalamus primary visual cortex entorhinal cortex Pars compacta parietal lobe external globus pallidus postcentral gyrus Top expressed in lateral septal nucleus ventromedial nucleus lateral geniculate nucleus visual cortex anterior amygdaloid area primary visual cortex lateral hypothalamus mammillary body primary motor cortex dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding tropomyosin binding Cellular component cytoplasm growth cone neuron projection cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping positive regulation of G protein-coupled receptor signaling pathway neuron-neuron synaptic transmission nervous system development learning or memory muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29767 50876 Ensembl ENSG00000128872 ENSMUSG00000032186 UniProt Q9NZR1 Q9JKK7 RefSeq (mRNA) NM_014548 NM_001142885 NM_001038710 NM_016711 RefSeq (protein) NP_001136357 NP_055363 NP_001033799 NP_057920 Location (UCSC) Chr 15: 51.75 – 51.82 Mb Chr 9: 75.47 – 75.52 Mb PubMed search [3] [4]
Wikidata
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Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.^[5]

Function[edit]

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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