PAPSS2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PAPSS2, ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603005; MGI: 1330223; HomoloGene: 55840; GeneCards: PAPSS2; OMA:PAPSS2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.[5][6]
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.[6]
PDB gallery
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2ax4: Crystal structure of the kinase domain of human 3'-phosphoadenosine 5'-phosphosulphate synthetase 2
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2.7.1-2.7.4: phosphotransferase/kinase (PO4) |
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2.7.6: diphosphotransferase (P2O7) |
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2.7.7: nucleotidyltransferase (PO4-nucleoside) |
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2.7.8: miscellaneous |
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2.7.10-2.7.13: protein kinase (PO4; protein acceptor) |
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glycosaminoglycan anabolism |
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glycosaminoglycan catabolism |
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This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it. |