Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).
There are three catalytic subunits that are classified as class IA PI 3-kinases:[citation needed]
There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:[citation needed]
Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).
The only known class IB PI 3-kinase catalytic subunit is p110γ.
There are two known regulatory subunits for p110γ:
| |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2.7.1-2.7.4: phosphotransferase/kinase (PO4) |
| ||||||||||||||
2.7.6: diphosphotransferase (P2O7) |
| ||||||||||||||
2.7.7: nucleotidyltransferase (PO4-nucleoside) |
| ||||||||||||||
2.7.8: miscellaneous |
| ||||||||||||||
2.7.10-2.7.13: protein kinase (PO4; protein acceptor) |
|
| |
---|---|
Activity |
|
Regulation |
|
Classification |
|
Kinetics |
|
Types |
|
This EC 2.7 enzyme-related article is a stub. You can help Wikipedia by expanding it. |
![]() | This cell biology article is a stub. You can help Wikipedia by expanding it. |