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1 References  













Proheptazine






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From Wikipedia, the free encyclopedia
  

Proheptazine
Clinical data
ATC code
  • none
Legal status
Legal status
  • AU: S9 (Prohibited substance)
  • BR: Class A1 (Narcotic drugs)[1]
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • US: Schedule I
    • Identifiers

    • 1,3-Dimethyl-4-phenylazepan-4-yl propionate

    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    CompTox Dashboard (EPA)
    ECHA InfoCard100.000.916 Edit this at Wikidata
    Chemical and physical data
    FormulaC17H25NO2
    Molar mass275.392 g·mol−1
    3D model (JSmol)

    • O=C(OC2(c1ccccc1)CCCN(C)CC2C)CC

    • InChI=1S/C17H25NO2/c1-4-16(19)20-17(15-9-6-5-7-10-15)11-8-12-18(3)13-14(17)2/h5-7,9-10,14H,4,8,11-13H2,1-3H3 checkY

    • Key:ZXWAUWBYASJEOE-UHFFFAOYSA-N checkY

      (verify)

    Proheptazine is an opioid analgesic related to pethidine. It was invented in the 1960s.[2]

    Proheptazine produces similar effects to other opioids,[3] including analgesia, sedation, euphoria, dizziness and nausea.

    In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9643 and a 2013 annual aggregate manufacturing quota of zero. The salts in use are the citrate (free base conversion ratio 0.589), hydrobromide (0.773), and hydrochloride (0.883).[4][5]

    References[edit]

    1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  • ^ Diamond J, Bruce WF, Tyson FT (January 1964). "Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine)". Journal of Medicinal Chemistry. 7: 57–60. doi:10.1021/jm00331a013. PMID 14186026.
  • ^ Finney ZG, Riley TN (August 1980). "4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido)perhydroazepines as ring-expanded analogues". Journal of Medicinal Chemistry. 23 (8): 895–9. doi:10.1021/jm00182a016. PMID 7190616.
  • ^ "Quotas - 2014". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.
  • ^ "Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.



    • Stub icon

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Proheptazine&oldid=1221668036"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Opioids
     ●Azepanes
     ●Propionate esters
     ●Mu-opioid receptor agonists
     ●Analgesic stubs
     Hidden categories: 
    ●CS1 Brazilian Portuguese-language sources (pt-br)
     ●Articles with short description
     ●Short description is different from Wikidata
     ●ECHA InfoCard ID from Wikidata
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     ●All stub articles
      


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