Inorganic chemistry, a radical-substitution reaction is a substitution reaction involving free radicals as a reactive intermediate.[1]
The reaction always involves at least two steps, and possibly a third.
In the first step called initiation (2,3), a free radical is created by homolysis. Homolysis can be brought about by heat or ultraviolet light, but also by radical initiators such as organic peroxidesorazo compounds. UV Light is used to create two free radicals from one diatomic species. The final step is called termination (6,7), in which the radical recombines with another radical species. If the reaction is not terminated, but instead the radical group(s) go on to react further, the steps where new radicals are formed and then react are collectively known as propagation (4,5). This is because a new radical is created, able to participate in secondary reactions.
Infree radical halogenation reactions, radical substitution takes place with halogen reagents and alkane substrates. Another important class of radical substitutions involve aryl radicals. One example is the hydroxylation of benzenebyFenton's reagent. Many oxidation and reduction reactions in organic chemistry have free radical intermediates, for example the oxidation of aldehydestocarboxylic acids with chromic acid. Coupling reactions can also be considered radical substitutions. Certain aromatic substitutions takes place by radical-nucleophilic aromatic substitution. Auto-oxidation is a process responsible for deterioration of paints and food, as well as production of certain lab hazards such as diethyl ether peroxide.
More radical substitutions are listed below:
