Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 References

Rolitetracycline

●فارسی ●Italiano ●Română ●Српски / srpski ●Srpskohrvatski / српскохрватски ●ไทย Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version In other projects ●Wikimedia Commons Appearance From Wikipedia, the free encyclopedia

This article needs additional citations for verification. Please help improve this articlebyadding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Rolitetracycline" – news · newspapers · books · scholar · JSTOR (December 2014) (Learn how and when to remove this message)

Rolitetracycline
Clinical data


Other names	(2Z,4S,4aS,5aS,6S,12aS)-4-Dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(pyrrolidin-1-ylmethylamino)methylidene]-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
ATC code	J01AA09 (WHO)
Identifiers
IUPAC name (2Z,4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(pyrrolidin-1-ylmethyl)amino]methylene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
CAS Number	751-97-3^Y
PubChem CID	54682938
DrugBank	DB01301^Y
ChemSpider	10469507^Y
UNII	GH9IW85221
KEGG	D02282^Y
ChEMBL	ChEMBL1214184^N
CompTox Dashboard (EPA)	DTXSID7023568
ECHA InfoCard	100.010.938
Chemical and physical data
Formula	C₂₇H₃₃N₃O₈
Molar mass	527.574 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(NCN1CCCC1)\C2=C(/O)[C@@H](N(C)C)[C@@H]3CC5C(=C(\O)[C@]3(O)C2=O)\C(=O)c4c(O)cccc4[C@@]5(C)O
InChI InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14?,15-,20-,26+,27-/m0/s1^Y Key:HMEYVGGHISAPJR-VQCPGFMQSA-N^Y
^NY (what is this?) (verify)

Rolitetracycline is a tetracycline antibiotic.^[1] Tetracycline is N-Mannich base prodrug that is prepared from tetracycline by condensation with pyrrolidine and formaldehyde to produce rolitetracycline. Rolitetracycline is used as an antibacterial drug, a protein synthesis inhibitor, an antiprotozoal drug and a prodrug.^[2]^[3]

References[edit]

^ "Rolitetracycline". PubChem. National Library of Medicine. Retrieved 8 June 2020.

^ PubChem. "Rolitetracycline". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-07-29.

^ Smith L (January 1964). "Rolitetracycline, an antibiotic for parenteral use. (syntetrin, velacycline)". JAMA. 187 (2): 141. doi:10.1001/jama.1964.03060150065017. PMID 14066734.

-mycin (Streptomyces)

-micin (Micromonospora)

other

Tetracyclines

Macrolides	Azithromycin^# Boromycin Carbomycin Carrimycin Clarithromycin^# Dirithromycin Erythromycin^# Flurithromycin Gamithromycin Josamycin Kitasamycin Midecamycin Miocamycin Oleandomycin Rokitamycin Roxithromycin Solithromycin Spiramycin Telithromycin Tildipirosin Tilmicosin Troleandomycin Tulathromycin Tylosin Tylvalosin
Ketolides	Telithromycin^‡ Cethromycin Solithromycin^†
Lincosamides	Clindamycin^# Lincomycin Pirlimycin
Streptogramins	Pristinamycin (IA, IIA, IIB) NXL103 (Flopristin, Linopristin) Quinupristin/dalfopristin (Dalfopristin, Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

Steroid antibacterials

^‡Withdrawn from market

This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it.