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1 References  













Satavaptan






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From Wikipedia, the free encyclopedia
  

Satavaptan
Clinical data
ATC code
  • none
Identifiers

  • N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide

CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard100.211.853 Edit this at Wikidata
Chemical and physical data
FormulaC33H45N3O8S
Molar mass643.80 g·mol−1
3D model (JSmol)

  • C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C

  • InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+ ☒N

  • Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N ☒N

 ☒NcheckY (what is this?)  (verify)

Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist[1] which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites.[2] Development was discontinued in 2009.[3]

References[edit]

  1. ^ Soupart A, Gross P, Legros JJ, Alföldi S, Annane D, Heshmati HM, Decaux G (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clinical Journal of the American Society of Nephrology. 1 (6): 1154–60. doi:10.2215/CJN.00160106. PMID 17699341.
  • ^ Ginès P, Wong F, Watson H, Milutinovic S, del Arbol LR, Olteanu D (July 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial". Hepatology. 48 (1): 204–13. doi:10.1002/hep.22293. PMID 18508290.
  • ^ "Satavaptan". Adis Insight. Springer Nature Switzerland AG.
    • Stub icon

    This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Satavaptan&oldid=1227081586"
    Categories: 
    ●Drugs not assigned an ATC code
     ●Diuretics
     ●Tert-butyl compounds
     ●Vasopressin receptor antagonists
     ●Benzamides
     ●4-Morpholinyl compounds
     ●Ethanolamines
     ●Cyclohexanols
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