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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Sitagliptin/metformin , sold under the brand name Janumet among others, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes .[8] metformin and a sulfonylurea .[8] [9] by mouth .[8]
Common side effects include diarrhea, headache, and upper respiratory tract infections.[5] lactic acidosis , pancreatitis , low blood sugar , heart failure , joint pain, and allergic reactions .[5] pregnant or breastfeeding .[1] sitagliptin (a dipeptidyl peptidase-4 inhibitor ) and metformin (a biguanide ).[5]
The combination was approved for medical use in the United States in 2007.[5] million prescriptions.[10] [11] [12] [13]
Medical uses
[ edit ]
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes .[5] [6]
In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people inadequately controlled on their maximal tolerated dose of metformin and a sulfonylurea; as triple combination therapy with a peroxisome proliferator-activated receptor (PPAR) agonist (i.e., a thiazolidinedione ) as an adjunct to diet and exercise in people inadequately controlled on their maximal tolerated dose of metformin and a PPAR agonist; and as add-on to insulin as an adjunct to diet and exercise to improve glycemic control in people when stable dosage of insulin and metformin alone do not provide adequate glycemic control."[7]
In December 2020, the U.S. Food and Drug Administration (FDA) approved labeling changes stating that Januvia (sitagliptin), Janumet (sitagliptin and metformin hydrochloride), and Janumet XR (sitagliptin and metformin hydrochloride extended-release) are not proven to improve glycemic (blood sugar) control in children aged 10 to 17 with type 2 diabetes.[14] [14]
Society and culture
[ edit ]
Brand names
[ edit ]
As of 2018, the combination is marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, Velmetia, Istamet, Emsita, Sitaglyn, Sitazit-M and Zaxoran.[15]
References
[ edit ]
^ "Product monograph brand safety updates" . Health Canada . February 2024. Retrieved 24 March 2024 .
^ "Janumet 50 mg/1000 mg film-coated tablets - Summary of Product Characteristics (SmPC)" . (emc) . 25 November 2020. Archived from the original on 26 October 2020. Retrieved 5 December 2020 .
^ a b c d e f "Janumet- sitagliptin and metformin hydrochloride tablet, film coated" . DailyMed . 12 August 2019. Archived from the original on 9 June 2021. Retrieved 5 December 2020 .
^ a b "Janumet XR- sitagliptin and metformin hydrochloride tablet, film coated, extended release" . DailyMed . Archived from the original on 29 October 2020. Retrieved 5 December 2020 .
^ a b "Janumet EPAR" . European Medicines Agency (EMA)Archived from the original on 9 June 2021. Retrieved 5 December 2020 .
^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 682. ISBN 9780857113382
^ Hayes J, Anderson R, Stephens JW (2016). "Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy" . Drug Design, Development and Therapy . 10 doi :10.2147/DDDT.S93076 PMC 4958358 PMID 27486305 .
^ "The Top 300 of 2021" . ClinCalc . Archived from the original on 15 January 2024. Retrieved 14 January 2024 .
^ "Metformin; Sitagliptin - Drug Usage Statistics" . ClinCalc . Retrieved 14 January 2024 .
^ "Sitagliptin / Metformin hydrochloride Accord EPAR" . European Medicines Agency (EMA)Archived from the original on 3 August 2022. Retrieved 3 August 2022 .
^ "Sitagliptin / Metformin hydrochloride Sun: Pending EC decision" . European Medicines Agency (EMA)Archived from the original on 27 January 2023. Retrieved 28 January 2023 .
^ a b "New studies show diabetes drug not proven to improve blood sugar control in pediatric patients" . U.S. Food and Drug Administration . 4 December 2020. Archived from the original on 4 December 2020. Retrieved 5 December 2020 .public domain .
^ "International brands for Sitagliptin/metformin" . Drugs.com. Archived from the original on 23 August 2019. Retrieved 3 September 2018 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Sitagliptin/metformin&oldid=1215289361 " C a t e g o r i e s : ● C o m b i n a t i o n d i a b e t e s d r u g s ● D r u g s d e v e l o p e d b y M e r c k & C o . ● G a s t r o i n t e s t i n a l s y s t e m d r u g s t u b s H i d d e n c a t e g o r i e s : ● S o u r c e a t t r i b u t i o n ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● U s e d m y d a t e s f r o m A u g u s t 2 0 2 2 ● D r u g s w i t h n o n - s t a n d a r d l e g a l s t a t u s ● C h e m i c a l a r t i c l e s w i t h o u t C A S r e g i s t r y n u m b e r ● A r t i c l e s w i t h o u t E B I s o u r c e ● C h e m i c a l p a g e s w i t h o u t C h e m S p i d e r I D ● C h e m i c a l p a g e s w i t h o u t D r u g B a n k i d e n t i f i e r ● A r t i c l e s w i t h o u t I n C h I s o u r c e ● A r t i c l e s w i t h o u t U N I I s o u r c e ● A r t i c l e s c o n t a i n i n g u n v e r i f i e d c h e m i c a l i n f o b o x e s ● D r u g s t h a t a r e a c o m b i n a t i o n o f c h e m i c a l s ● W i k i p e d i a m e d i c i n e a r t i c l e s r e a d y t o t r a n s l a t e ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 4 M a r c h 2 0 2 4 , a t 0 6 : 2 4 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
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