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Clinical data | |
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Other names | (1α,24R)-1,24-Dihydroxyvitamin D3 |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Topical |
ATC code | |
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ECHA InfoCard | 100.220.855 ![]() |
Chemical and physical data | |
Formula | C27H44O3 |
Molar mass | 416.646 g·mol−1 |
3D model (JSmol) | |
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Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog.[1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
It is on the World Health Organization's List of Essential Medicines.[2]
Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptorsonkeratinocytes.[3][4]
It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover.[1] It is available as an ointment or lotion.
It has also been used for vitiligo[5][6] and Hailey-Hailey disease.[7]
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Topical |
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Systemic |
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Fat soluble |
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Water soluble |
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