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ECHA InfoCard | 100.011.824 ![]() |
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Formula | C23H32N2O2S |
Molar mass | 400.58 g·mol−1 |
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Thiocarlide (ortiocarlideorisoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid.[1]
Thiocarlide has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis.[2] Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.[citation needed]
Thiocarlide was developed by a Belgian company, Continental Pharma S.A. Belgo-Canadienne in Brussels, Belgium. The head researcher was Professor N. P. Buu-Hoi, head of Continental Pharma's Research Division.[citation needed]
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Nucleic acid inhibitor |
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Protein synthesis inhibitor |
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Cell envelope antibiotic |
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