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(Top) 1 Mechanism 2 References 3 External links

Tromantadine

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Tromantadine
Clinical data

Trade names	Viru-Merz
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical (gel)
ATC code	D06BB02 (WHO) J05AC03 (WHO)
Legal status
Legal status	US: Not FDA-approved OTC (RU)
Identifiers
IUPAC name N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
CAS Number	53783-83-8^N
PubChem CID	64377
ChemSpider	57947^Y
UNII	H191JFG8WA
KEGG	D07199^Y
NIAID ChemDB	007760
CompTox Dashboard (EPA)	DTXSID00202062
ECHA InfoCard	100.053.409
Chemical and physical data
Formula	C₁₆H₂₈N₂O₂
Molar mass	280.412 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C
InChI InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)^Y Key:UXQDWARBDDDTKG-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.^[1]^[2]

Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane.

Mechanism[edit]

Tromantadine inhibits the early and late events in the virus replication cycle.^[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.^{[citation needed]}

References[edit]

^ Ostheimer KE, Busch T, Görtelmeyer R, Hahn KD (September 1989). "Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis". Arzneimittel-Forschung. 39 (9): 1152–1155. PMID 2686658.

^ Diezel W, Michel G, Görtelmeyer R, Ostheimer KE (April 1993). "Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial". Arzneimittel-Forschung. 43 (4): 491–496. PMID 8494582.