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Clinical data | |
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Trade names | Sulfamylon, Mafylon |
AHFS/Drugs.com | Monograph |
Routes of administration | Topical |
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ECHA InfoCard | 100.004.843 |
Chemical and physical data | |
Formula | C7H10N2O2S |
Molar mass | 186.23 g·mol−1 |
3D model (JSmol) | |
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NY (what is this?) (verify) |
Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.[citation needed]
Mafenide is used to treat severe burns.[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisoloneorbacitracin are more appropriate for facial burns.[3]
Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. [citation needed]
Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.[4]
There are no significant interactions.[citation needed]
Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.
For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.[citation needed]
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Antibiotics |
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Chemotherapeutics |
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Antifolates (inhibit bacterial purine metabolism, thereby inhibiting DNA and RNA synthesis) |
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Quinolones (inhibit bacterial topoisomerase and/or DNA gyrase, thereby inhibiting DNA replication) |
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Anaerobic DNA inhibitors |
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RNA synthesis |
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