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C o n t r i b u t e
● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t ● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t ● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 R e f e r e n c e s
2 E x t e r n a l l i n k s
T o g g l e t h e t a b l e o f c o n t e n t s
T r y p t o p h a n N - m o n o o x y g e n a s e
2 l a n g u a g e s
● С р п с к и / s r p s k i ● S r p s k o h r v a t s k i / с р п с к о х р в а т с к и
E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
● R e a d ● E d i t ● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
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G e n e r a l
● W h a t l i n k s h e r e ● R e l a t e d c h a n g e s ● U p l o a d f i l e ● S p e c i a l p a g e s ● P e r m a n e n t l i n k ● P a g e i n f o r m a t i o n ● C i t e t h i s p a g e ● G e t s h o r t e n e d U R L ● D o w n l o a d Q R c o d e ● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Tryptophan N-monooxygenase (EC 1.14.13.125 , tryptophan N-hydroxylase , CYP79B1 , CYP79B2 , CYP79B3 ) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) .[1] [2] [3] [4] catalyses the following chemical reaction
L-tryptophan + 2 O2 +
⇌
{\displaystyle \rightleftharpoons }
E )-indol-3-ylacetaldoxime + 2 NADP+ + CO2 2
(1a) L-tryptophan + O2 +
⇌
{\displaystyle \rightleftharpoons }
+ + H2 O
(1b) N-hydroxy-L-tryptophan + O2 +
⇌
{\displaystyle \rightleftharpoons }
+ + H2 O
(1c) N,N-dihydroxy-L-tryptophan
⇌
{\displaystyle \rightleftharpoons }
E )-indol-3-ylacetaldoxime + CO2 2 O
Tryptophan N-monooxygenase is a heme -thiolate protein (P-450).
References [ edit ]
^ Zhao Y, Hull AK, Gupta NR, Goss KA, Alonso J, Ecker JR, Normanly J, Chory J, Celenza JL (December 2002). "Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3" . Genes & Development . 16 23 ): 3100–12. doi :10.1101/gad.1035402 . PMC 187496 PMID 12464638 .
^ Naur P, Hansen CH, Bak S, Hansen BG, Jensen NB, Nielsen HL, Halkier BA (January 2003). "CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime". Archives of Biochemistry and Biophysics . 409 (1 ): 235–41. doi :10.1016/s0003-9861(02 )00567-2 . PMID 12464264 .
External links [ edit ]
t
e
Activity
Regulation
Classification
Kinetics
Types
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Tryptophan_N-monooxygenase&oldid=1185015924 " C a t e g o r y : ● E C 1 . 1 4 . 1 3 H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a
● T h i s p a g e w a s l a s t e d i t e d o n 1 4 N o v e m b e r 2 0 2 3 , a t 0 1 : 0 9 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
(E)-indol-3-ylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
