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Tyrosine N-monooxygenase

Tyrosine N-monooxygenase (EC 1.14.13.41, tyrosine N-hydroxylase, CYP79A1) is an enzyme with systematic name L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

L-tyrosine + 2 O₂ + 2 NADPH + 2 H⁺ ${\displaystyle \rightleftharpoons }$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP⁺ + CO₂ + 3 H₂O (overall reaction)

(1a) L-tyrosine + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N-hydroxy-L-tyrosine + NADP⁺ + H₂O

(1b) N-hydroxy-L-tyrosine + O₂ + NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ N,N-dihydroxy-L-tyrosine + NADP⁺ + H₂O

(1c) N,N-dihydroxy-L-tyrosine ${\displaystyle \rightleftharpoons }$ (Z)-[4-hydroxyphenylacetaldehyde oxime] + CO₂ + H₂O

Tyrosine N-monooxygenase is heme-thiolate protein (P-450).

References[edit]

External links[edit]

• Tyrosine+N-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)