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1 References  













Udenafil






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From Wikipedia, the free encyclopedia
  

Udenafil
Clinical data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • US: Not approved
  • In general: ℞ (Prescription only)
    • Pharmacokinetic data
    Protein binding93,9%
    MetabolismLiver (mainly CYP3A4)
    Elimination half-life7.3–12.1 hours
    ExcretionBiliary
    Identifiers

    • 3-(1-Methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide

    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC25H36N6O4S
    Molar mass516.66 g·mol−1
    3D model (JSmol)

    • O=C2\N=C(/Nc1c(nn(c12)C)CCC)c3cc(ccc3OCCC)S(=O)(=O)NCCC4N(C)CCC4

    • InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32) checkY

    • Key:IYFNEFQTYQPVOC-UHFFFAOYSA-N checkY

     ☒NcheckY (what is this?)  (verify)

    The drug udenafil is marketed under the trade name Zydena. It is within the PDE5 inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Like other PDE5 inhibitors, it is used to treat erectile dysfunction. Udenafil was developed by Dong-A Pharmaceutical.[1] It has fairly rapid onset of action (peak plasma concentration after 1 to 1.5 hours), and has long duration of action (plasma half-life of 11 to 13 hours). Udenafil's pharmacokinetics allows once-daily dosage (in addition to on-demand use).[2] Typical doses are 100 and 200 mg. Udenafil is available in Korea, Russia, and the Philippines.[3] It has not yet been approved for use in the United States by the U.S. Food and Drug Administration.

    References

    [edit]
    1. ^ Zydena (udenafil) product-information page. Dong-A Pharmaceutical. Retrieved on April 13, 2009.
  • ^ Kang SG, Kim JJ (April 2013). "Udenafil: efficacy and tolerability in the management of erectile dysfunction". Therapeutic Advances in Urology. 5 (2): 101–10. doi:10.1177/1756287212470019. PMC 3607490. PMID 23554845.
  • ^ "Zydena". Drugs.com.
    • Stub icon

    This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

  • t
  • e

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Udenafil&oldid=1156287159"
    Categories: 
    ●Lactams
     ●PDE5 inhibitors
     ●Phenol ethers
     ●Pyrazolopyrimidines
     ●Pyrrolidines
     ●Sulfonamides
     ●Genito-urinary system drug stubs
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     ●Short description matches Wikidata
     ●Drugs with non-standard legal status
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    ●This page was last edited on 22 May 2023, at 04:15 (UTC).
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