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==Synthesis== |
==Synthesis== |
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[[File:Tiamenidine-synthesis.svg|700px|center|thumb|Tiamenidine synthesis:<ref>Rippel, H.; Ruschig, H.; Linder, E.; Schorr, M.; 1973, {{US Patent|3,758,476}}</ref>]] |
[[File:Tiamenidine-synthesis.svg|700px|center|thumb|Tiamenidine synthesis:<ref>Rippel, H.; Ruschig, H.; Linder, E.; Schorr, M.; 1973, {{US Patent|3,758,476}}</ref>]] |
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Reaction of thiourea '''1''' with [[methyliodide]] gives the corresponding S-methyl analogue ('''2'''), followed by heating with [[ethylenediamine]], completes the synthesis of Tiamenidine ('''3'''). |
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Tiamenidine can be prepared from 1-(2-chloro-4-methylthiophen-3-yl)thiourea. |
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==References== |
==References== |
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Identifiers | |
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PubChem CID | |
ChemSpider |
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UNII | |
KEGG |
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ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C8H10ClN3S |
Molar mass | 215.70 g/mol g·mol−1 |
3D model (JSmol) | |
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Tiamenidine is a compound that shares many of the pharmacological properties of clonidine.
Reaction of thiourea 1 with methyliodide gives the corresponding S-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of Tiamenidine (3).
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Sympatholytics (antagonize α-adrenergic vasoconstriction) |
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Other antagonists |
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α1 |
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α2 |
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β |
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