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1 Synthesis  





2 References  














Tiamenidine: Difference between revisions






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==Synthesis==

==Synthesis==

[[File:Tiamenidine-synthesis.svg|700px|center|thumb|Tiamenidine synthesis:<ref>Rippel, H.; Ruschig, H.; Linder, E.; Schorr, M.; 1973, {{US Patent|3,758,476}}</ref>]]

[[File:Tiamenidine-synthesis.svg|700px|center|thumb|Tiamenidine synthesis:<ref>Rippel, H.; Ruschig, H.; Linder, E.; Schorr, M.; 1973, {{US Patent|3,758,476}}</ref>]]

Reaction of thiourea '''1''' with [[methyliodide]] gives the corresponding S-methyl analogue ('''2'''), followed by heating with [[ethylenediamine]], completes the synthesis of Tiamenidine ('''3''').

Tiamenidine can be prepared from 1-(2-chloro-4-methylthiophen-3-yl)thiourea.



==References==

==References==


Revision as of 11:23, 28 July 2015

Tiamenidine
Identifiers
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H10ClN3S
Molar mass215.70 g/mol g·mol−1
3D model (JSmol)
  • Clc2scc(c2N/C1=N/CCN1)C

  • InChI=1S/C8H10ClN3S/c1-5-4-13-7(9)6(5)12-8-10-2-3-11-8/h4H,2-3H2,1H3,(H2,10,11,12) checkY

  • Key:CVWILQHZFWRYPB-UHFFFAOYSA-N checkY

  (verify)

Tiamenidine is a compound that shares many of the pharmacological properties of clonidine.

Synthesis

Tiamenidine synthesis:[1]

Reaction of thiourea 1 with methyliodide gives the corresponding S-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of Tiamenidine (3).

References

  1. ^ Rippel, H.; Ruschig, H.; Linder, E.; Schorr, M.; 1973, U.S. patent 3,758,476



Retrieved from "https://en.wikipedia.org/w/index.php?title=Tiamenidine&oldid=673453890"

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This page was last edited on 28 July 2015, at 11:23 (UTC).

This version of the page has been revised. Besides normal editing, the reason for revision may have been that this version contains factual inaccuracies, vandalism, or material not compatible with the Creative Commons Attribution-ShareAlike License.



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