Contents

ADAMTS9

Protein-coding gene in the species Homo sapiens

ADAMTS9
Identifiers
Aliases	ADAMTS9, ADAM metallopeptidase with thrombospondin type 1 motif 9
External IDs	OMIM: 605421; MGI: 1916320; HomoloGene: 18821; GeneCards: ADAMTS9; OMA:ADAMTS9 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.1 Start 64,515,654 bp[1] End 64,688,000 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 92,749,680 bp[2] End 92,920,473 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve endometrium parietal pleura body of uterus right ventricle pericardium upper lobe of left lung left uterine tube left coronary artery ascending aorta Top expressed in renal corpuscle gastrula molar external carotid artery cumulus cell vas deferens left lung lobe dermis Gonadal ridge efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding peptidase activity metalloendopeptidase activity endopeptidase activity hydrolase activity metallopeptidase activity metal ion binding Cellular component extracellular region cell surface extracellular space extracellular matrix endoplasmic reticulum intracellular membrane-bounded organelle collagen-containing extracellular matrix Biological process multicellular organism development protein transport regulation of developmental pigmentation vesicle-mediated transport positive regulation of melanocyte differentiation proteolysis glycoprotein catabolic process heart valve morphogenesis ventricular cardiac muscle tissue development negative regulation of endothelial cell migration extracellular matrix organization aorta morphogenesis endothelial cell-matrix adhesion negative regulation of sprouting angiogenesis response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56999 101401 Ensembl ENSG00000163638 ENSMUSG00000030022 UniProt Q9P2N4 n/a RefSeq (mRNA) NM_182920 NM_001318781 NM_020249 NM_182921 NM_175314 RefSeq (protein) NP_001305710 NP_891550 n/a Location (UCSC) Chr 3: 64.52 – 64.69 Mb Chr 6: 92.75 – 92.92 Mb PubMed search [3] [4]
Wikidata
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A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene.^[5][6]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors.^[6]

• The MEROPS online database for peptidases and their inhibitors: M12.021
• Human ADAMTS9 genome location and ADAMTS9 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.