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Contents

   



(Top)
  


1 Function  




2 References  




3 Further reading  




4 External links  













MMP21






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From Wikipedia, the free encyclopedia
  

MMP21
Identifiers
AliasesMMP21, MMP-21, HTX7, matrix metallopeptidase 21
External IDsOMIM: 608416; MGI: 2664387; HomoloGene: 17519; GeneCards: MMP21; OMA:MMP21 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

118856

214766

Ensembl

ENSG00000154485

ENSMUSG00000030981

UniProt

Q8N119

Q8K3F2

RefSeq (mRNA)

NM_147191

NM_152944
NM_001320216

RefSeq (protein)

NP_671724

NP_001307145
NP_694423

Location (UCSC)Chr 10: 125.75 – 125.78 MbChr 7: 133.28 – 133.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.[5][6]

Function

[edit]

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154485 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030981 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
  • ^ a b "Entrez Gene: MMP21 matrix metallopeptidase 21".

    • Further reading

    [edit]
  • Bister V, Skoog T, Virolainen S, et al. (2008). "Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma". Mod. Pathol. 20 (11): 1128–40. doi:10.1038/modpathol.3800956. PMID 17873896.
  • Skoog T, Ahokas K, Orsmark C, et al. (2006). "MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture". Exp. Dermatol. 15 (10): 775–83. doi:10.1111/j.1600-0625.2006.00460.x. PMID 16984259. S2CID 5605938.
  • Ahokas K, Karjalainen-Lindsberg ML, Sihvo E, et al. (2006). "Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer". Tumour Biol. 27 (3): 133–41. doi:10.1159/000092774. PMID 16641547. S2CID 21325640.
  • Shagisultanova EI, Novikova IA, Sidorenko YS, et al. (2004). "The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer". Anticancer Res. 24 (1): 199–201. PMID 15015597.
  • Ahokas K, Lohi J, Illman SA, et al. (2004). "Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes". Lab. Invest. 83 (12): 1887–99. doi:10.1097/01.LAB.0000106721.86126.39. PMID 14691307.
  • Marchenko GN, Marchenko ND, Strongin AY (2003). "The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein". Biochem. J. 372 (Pt 2): 503–15. doi:10.1042/BJ20030174. PMC 1223413. PMID 12617721.
  • Ahokas K, Lohi J, Lohi H, et al. (2003). "Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer". Gene. 301 (1–2): 31–41. doi:10.1016/S0378-1119(02)01088-0. PMID 12490321.
    • [edit]


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=MMP21&oldid=1116598998"
    Categories: 
    ●Genes on human chromosome 10
     ●Matrix metalloproteinases
     ●EC 3.4.24
     ●Human chromosome 10 gene stubs
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    ●This page was last edited on 17 October 2022, at 11:18 (UTC).
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