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Contents

   



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1 References  




2 Further reading  




3 External links  













ADAM18






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From Wikipedia, the free encyclopedia
  

ADAM18
Identifiers
AliasesADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDsMGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8749

13524

Ensembl

ENSG00000168619
ENSG00000278548

ENSMUSG00000031552

UniProt

Q9Y3Q7

Q9R157

RefSeq (mRNA)

NM_001190956
NM_014237
NM_001320313

NM_010084

RefSeq (protein)

NP_001177885
NP_001307242
NP_055052

NP_034214

Location (UCSC)Chr 8: 39.58 – 39.73 MbChr 8: 25.09 – 25.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[6]

References[edit]

  1. ^ a b c ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 – Ensembl, May 2017
  • ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031552 – Ensembl, May 2017
  • ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  • ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
  • ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

    • Further reading[edit]

  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
  • Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

    • External links[edit]


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=ADAM18&oldid=1166576811"
    Categories: 
    ●Genes on human chromosome 8
     ●Proteases
     ●Human proteins
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     ●Human chromosome 8 gene stubs
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    ●This page was last edited on 22 July 2023, at 13:22 (UTC).
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