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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Antiprogestogens , or antiprogestins , also known as progesterone antagonists or progesterone blockers , are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body. These drugs competitively inhibit progestin at progesterone receptors. They act by blocking the progesterone receptor (PR )and/or inhibiting or suppressing progestogen production . Antiprogestogens are one of three types of sex hormone antagonists , the others being antiestrogens and antiandrogens .[1]
Antiprogestogens are used as abortifacients and emergency contraceptives and in the treatment of uterine fibroids . They are also being studied in the treatment of breast cancer . Examples of antiprogestogens include the progesterone receptor weak partial agonist mifepristone , the selective progesterone receptor modulator (SPRM) ulipristal acetate , and the silent antagonist aglepristone .[2] [3] medical abortion , mifepristone is combined with a prostaglandin (e.g., gemeprost ). Ulipristal is used as a form of emergency contraception. [4]
Several hundred antiprogestogens have been developed, but only three, mifepristone , lilopristone , and onapristone , have been given to humans, and of these, only mifepristone has been approved and introduced for clinical use.[5]
Progestins, including progesterone are important for the body to prepare the uterus for implantation of fertilized egg during the luteal phase of the menstrual cycle and, if fertilization, implantation, and other events necessary for pregnancy occur, increased progestin (i.e. progesterone) levels are heavily involved in maintaining the pregnancy. Blocking the effects of progestins, such as progesterone, is associated with anti-gestational events. [6]
See also
[ edit ]
References
[ edit ]
^ Spitz, IM. (Oct 2006). "Progesterone receptor antagonists". Curr Opin Investig Drugs . 7 10 ): 882–90. PMID 17086932 .
^ Tang, OS.; Ho, PC. (Dec 2006). "Clinical applications of mifepristone". Gynecol Endocrinol . 22 12 ): 655–9. doi :10.1080/09513590601005946 . PMID 17162706 . S2CID 23295715 .
^ Le, Tao; Bhushan, Vikas; Qiu, Connie; Chalise, Anup; Kaparaliotis, Panagiotis (2023). First Aid . McGraw Hill.
^ Thomas H. Bourne; George Condous (17 October 2006). Handbook of Early Pregnancy Care ISBN 978-0-203-01621-3
^ Le, Tao; Bhushan, Vikas; Qiu, Connie; Chalise, Anup; Kaparaliotis, Panagiotis (2023). First Aid . McGraw Hill.
External links
[ edit ]
public domain material from Dictionary of Cancer Terms U.S. National Cancer Institute .
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PR Tooltip Progesterone receptor
Agonists
Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone
6,6-Difluoronorethisterone acetate
17α-Allyl-19-nortestosterone
Allylestrenol
Altrenogest
Chloroethynylnorgestrel
Cingestol
Danazol
Desogestrel
Dienogest
Ethinylandrostenediol
Ethisterone
Ethynerone
Etonogestrel
Etynodiol
Etynodiol diacetate
Gestodene
Gestrinone
Levonorgestrel
Levonorgestrel esters (e.g., levonorgestrel butanoate )
Lynestrenol
Lynestrenol phenylpropionate
Metynodiol
Metynodiol diacetate
Norelgestromin
Norethisterone (norethindrone)
Norethisterone esters (e.g., norethisterone acetate , norethisterone enanthate )
Noretynodrel
Norgesterone
Norgestimate
Norgestrel
Norgestrienone
Norvinisterone
Oxendolone
Quingestanol
Quingestanol acetate
Tibolone
Tigestol
Tosagestin ; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone
11β-Methyl-19-nortestosterone dodecylcarbonate
19-Nor-5-androstenediol
19-Nor-5-androstenedione
19-Nordehydroepiandrosterone
Bolandiol
Bolandiol dipropionate
Bolandione
Dimethisterone
Dienedione
Dienolone
Dimethandrolone
Dimethandrolone buciclate
Dimethandrolone dodecylcarbonate
Dimethandrolone undecanoate
Dimethyldienolone
Dimethyltrienolone
Ethyldienolone
Ethylestrenol (ethylnandrol)
Methyldienolone
Metribolone (R-1881)
Methoxydienone (methoxygonadiene)
Mibolerone
Nandrolone
Nandrolone esters (e.g., nandrolone decanoate , nandrolone phenylpropionate )
Norethandrolone
Normethandrone (methylestrenolone, normethandrolone, normethisterone)
RU-2309
Tetrahydrogestrinone
Trenbolone (trienolone)
Trenbolone esters (e.g., trenbolone acetate , trenbolone enanthate )
Trendione
Trestolone
Trestolone acetate
MixedSPRMs Tooltip Selective progesterone receptor modulators )
Antagonists
mPR Tooltip Membrane progesterone receptor PAQR Tooltip Progestin and adipoQ receptor )
See also
Receptor/signaling modulators
Progestogens and antiprogestogens
Androgen receptor modulators
Estrogen receptor modulators
List of progestogens
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Antiprogestogen&oldid=1183169578 " C a t e g o r i e s : ● A n t i p r o g e s t o g e n s ● A n t i n e o p l a s t i c a n d i m m u n o m o d u l a t i n g d r u g s t u b s ● G e n i t o - u r i n a r y s y s t e m d r u g s t u b s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● C o m m o n s c a t e g o r y l i n k i s o n W i k i d a t a ● W i k i p e d i a a r t i c l e s i n c o r p o r a t i n g t e x t f r o m t h e N a t i o n a l C a n c e r I n s t i t u t e D i c t i o n a r y o f C a n c e r T e r m s ● A l l s t u b a r t i c l e s
● T h i s p a g e w a s l a s t e d i t e d o n 2 N o v e m b e r 2 0 2 3 , a t 1 6 : 2 0 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
Media related to Antiprogestogens at Wikimedia Commons
This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.
