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Tosagestin

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Tosagestin
Clinical data

Other names	ORG-30659; Exogestin; Letogestin;^[1] 11-Methylene-δ¹⁵-norethisterone; 17α-Ethynyl-11-methylene-19-nor-δ¹⁵-testosterone
Routes of administration	By mouth
Identifiers
IUPAC name (1S,2R,10R,11S,14R,15S)-14-ethynyl-14-hydroxy-15-methyl-17-methylidenetetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-6,12-dien-5-one
CAS Number	110072-15-6
PubChem CID	159355
ChemSpider	140146
UNII	YS7Z529O22
KEGG	D06197
ChEMBL	ChEMBL2107658
CompTox Dashboard (EPA)	DTXSID50891344
Chemical and physical data
Formula	C₂₁H₂₄O₂
Molar mass	308.421 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC12CC(=C)C3C(C1C=CC2(C#C)O)CCC4=CC(=O)CCC34
InChI InChI=1S/C21H24O2/c1-4-21(23)10-9-18-17-7-5-14-11-15(22)6-8-16(14)19(17)13(2)12-20(18,21)3/h1,9-11,16-19,23H,2,5-8,12H2,3H3/t16-,17-,18-,19+,20-,21-/m0/s1 Key:YJSTYQGZKJHXLN-OLGWUGKESA-N

Tosagestin (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (developmental code name ORG-30659), also known as 11-methylene-δ¹⁵-norethisteroneor17α-ethynyl-11-methylene-19-nor-δ¹⁵-testosterone, is a progestin of the 19-nortestosterone group which was under development by Organon in the United States and Europe as a hormonal contraceptive (in combination with ethinylestradiol) and for the treatment of menopausal symptoms but was never marketed.^[2]^[3]^[4]^[5]^[6]

References[edit]

^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 2104. ISBN 978-3-527-30247-5.

^ World Health Organization (2013), The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances (PDF), p. 95, archived from the original (PDF) on August 8, 2016

^ "Tosagestin", AdisInsight, Springer Nature Switzerland AG, retrieved 12 July 2016

^ Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM (November 1998). "In vitro and in vivo metabolism of the progestagen Org 30659 in several species". Drug Metabolism and Disposition. 26 (11): 1102–1112. PMID 9806953.

^ de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, et al. (September 2003). "Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE)". Contraception. 68 (3): 195–202. doi:10.1016/S0010-7824(03)00140-9. PMID 14561540.