Arylsulfatase A (orcerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.[5][6]
A deficiency in Arylsulfatase A is associated with metachromatic leukodystrophy, an autosomal recessive disease.[7] Multiple sulfatase deficiency (MSD) is also associated with the ARSA gene.[8]
Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine.[9]
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PDB gallery
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1auk: HUMAN ARYLSULFATASE A
1e1z: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S
1e2s: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69A
1e33: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT P426L
1e3c: CRYSTAL STRUCTURE OF AN ARYLSULFATASE A MUTANT C69S SOAKED IN SYNTHETIC SUBSTRATE
1n2k: Crystal structure of a covalent intermediate of endogenous human arylsulfatase A
1n2l: Crystal structure of a covalent intermediate of endogenous human arylsulfatase A
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| 3.1.1: Carboxylic ester hydrolases |
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| 3.1.2: Thioesterase |
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| 3.1.3: Phosphatase |
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| 3.1.4: Phosphodiesterase |
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| 3.1.6: Sulfatase |
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| Nuclease (includes deoxyribonuclease and ribonuclease) |
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| Sphingolipid |
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| NCL |
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| Ceramide synthesis |
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