Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[4][5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.
The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[6]
PDB gallery
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2czh: Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) with phosphate ion (orthorhombic form)
2czi: Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) with calcium and phosphate ions
2czk: Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (trigonal form)
2ddk: Crystal structure of human myo-inositol monophosphatase 2 (IMPA2) (orthorhombic form)
2fvz: Human Inositol Monophosphosphatase 2
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3.1.1: Carboxylic ester hydrolases |
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3.1.2: Thioesterase |
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3.1.3: Phosphatase |
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3.1.4: Phosphodiesterase |
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3.1.6: Sulfatase |
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Nuclease (includes deoxyribonuclease and ribonuclease) |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Types |
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