Calpain-1 catalytic subunit (CANP 1) is a protein that in humans is encoded by the CAPN1 gene.[5][6][7]
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.[7]
CAPN1 has been shown to interact with PSEN2.[8]
PDB gallery
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1zcm: Human calpain protease core inhibited by ZLLYCH2F
2ary: Catalytic domain of Human Calpain-1
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