Contents

Cathepsin F

Protein-coding gene in the species Homo sapiens (Humans)

CTSF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M6D
Identifiers
Aliases	CTSF, CATSF, CLN13, cathepsin F
External IDs	OMIM: 603539; MGI: 1861434; HomoloGene: 31194; GeneCards: CTSF; OMA:CTSF - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,563,464 bp[1] End 66,568,879 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,905,158 bp[2] End 4,910,946 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left testis right testis right coronary artery left ovary right frontal lobe right ovary tibial nerve gastric mucosa ascending aorta Top expressed in neural layer of retina adrenal gland right kidney choroid plexus of fourth ventricle lip cerebellar cortex primary visual cortex epithelium of lens superior frontal gyrus dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity hydrolase activity cysteine-type endopeptidase activity Cellular component extracellular vesicle lysosome lysosomal lumen extracellular exosome extracellular space collagen-containing extracellular matrix Biological process proteolysis involved in cellular protein catabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8722 56464 Ensembl ENSG00000174080 ENSMUSG00000083282 UniProt Q9UBX1 Q9R013 RefSeq (mRNA) NM_003793 NM_019861 RefSeq (protein) NP_003784 NP_063914 Location (UCSC) Chr 11: 66.56 – 66.57 Mb Chr 19: 4.91 – 4.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cathepsin F is a protein that in humans is encoded by the CTSF gene.^[5][6][7]

Cysteine cathepsins are a familyofcysteine proteases that represent a major component of the lysosomal proteolytic system. In general, cathepsins contain a signal peptide, followed by a propeptide and then a catalytically active mature region. The very long (251-amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of Cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids that contains a 19-residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.^[7]

In non-human species[edit]

Immunodiagnosis of Opisthorchis viverrini[edit]

Opisthorchis viverrini, a parasite, is typically detected by stool examination, specifically by counting eggs. However, this non-invasive, "gold standard" method can be unreliable in light infection and labor-intensive. An ELISA assay that detects the presence of the parasite's cathepsin F protein may be used as an alternative way to test for the parasite's presence.^[8]

Discovery in Yesso scallop (Mizuhopecten yessoensis)[edit]

The Yesso scallop (Mizuhopecten yessoensis), was found in 2018 to express Cathepsin F in response to bacterial infection. The Yesso scallop has been suffering from high mortality due to bacterial diseases. Understanding the workings of its innate immune system, in various embryonic developmental stages, may help the associated aquaculture industry.^[9]

References[edit]

Further reading[edit]

External links[edit]

• The MEROPS online database for peptidases and their inhibitors: C01.018

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