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Contents

   



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1 See also  




2 References  




3 External links  













Caspase 4






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From Wikipedia, the free encyclopedia
  

caspase 4, apoptosis-related cysteine peptidase
Identifiers
SymbolCASP4
Alt. symbolsICE(rel)II, ICH-2, TX
NCBI gene837
HGNC1505
OMIM602664
RefSeqNM_001225
UniProtP49662
Other data
EC number3.4.22.57
LocusChr. 11 q22.2-q22.3
Search for
StructuresSwiss-model
DomainsInterPro

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.[1]

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.[2]

See also[edit]

References[edit]

  1. ^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.
  • ^ Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi:10.1016/j.chembiol.2017.02.003. PMC 5357154. PMID 28238723.

    • External links[edit]


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Caspase_4&oldid=1230824173"
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