Contents

Cathepsin H

Protein-coding gene in the species Homo sapiens

CTSH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BZN
Identifiers
Aliases	CTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
External IDs	OMIM: 116820; MGI: 107285; HomoloGene: 36159; GeneCards: CTSH; OMA:CTSH - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,921,058 bp[1] End 78,949,574 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.1|9 47.4 cM Start 89,936,205 bp[2] End 89,958,142 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve kidney tubule lower lobe of lung bronchial epithelial cell visceral pleura renal medulla monocyte lymph node upper lobe of lung human kidney Top expressed in left lung lobe right lung lobe yolk sac parotid gland right kidney mesenteric lymph nodes proximal tubule granulocyte cervix left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activator activity involved in apoptotic process cysteine-type peptidase activity HLA-A specific activating MHC class I receptor activity endopeptidase activity protein binding cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activity aminopeptidase activity serine-type endopeptidase activity hydrolase activity thyroid hormone binding peptidase activity Cellular component cytosol alveolar lamellar body lysosome extracellular exosome multivesicular body lumen extracellular region extracellular space secretory granule lumen intracellular membrane-bounded organelle tertiary granule lumen ficolin-1-rich granule lumen cytoplasmic ribonucleoprotein granule collagen-containing extracellular matrix Biological process surfactant homeostasis antigen processing and presentation adaptive immune response bradykinin catabolic process response to retinoic acid membrane protein proteolysis positive regulation of cell migration ERK1 and ERK2 cascade zymogen activation neuropeptide catabolic process positive regulation of epithelial cell migration positive regulation of apoptotic signaling pathway negative regulation of apoptotic process proteolysis positive regulation of angiogenesis positive regulation of peptidase activity positive regulation of gene expression protein destabilization cellular response to thyroid hormone stimulus positive regulation of cell population proliferation immune response-regulating signaling pathway proteolysis involved in cellular protein catabolic process metanephros development dichotomous subdivision of terminal units involved in lung branching T cell mediated cytotoxicity apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1512 13036 Ensembl ENSG00000103811 ENSMUSG00000032359 UniProt P09668 P49935 RefSeq (mRNA) NM_004390 NM_148979 NM_001319137 NM_007801 NM_001312649 RefSeq (protein) NP_001306066 NP_004381 NP_001299578 NP_031827 Location (UCSC) Chr 15: 78.92 – 78.95 Mb Chr 9: 89.94 – 89.96 Mb PubMed search [3] [4]
Wikidata
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Cathepsin H is a protein that in humans is encoded by the CTSH gene.^[5][6]

The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References[edit]

Further reading[edit]

External links[edit]

• The MEROPS online database for peptidases and their inhibitors: C01.040

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