Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.[5][6]
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.[7]
CAPN2 has been shown to interact with Bcl-2.[8]
PDB gallery
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1df0: CRYSTAL STRUCTURE OF M-CALPAIN
1kfu: Crystal Structure of Human m-Calpain Form II
1kfx: Crystal Structure of Human m-Calpain Form I
1mdw: Crystal Structure of Calcium-Bound Protease Core of Calpain II Reveals the Basis for Intrinsic Inactivation
1u5i: Crystal Structure analysis of rat m-calpain mutant Lys10 Thr
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