Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

Search

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

Contents

(Top) 1 See also 2 References 3 Further reading 4 External links

CD79B

●Deutsch ●فارسی ●Русский ●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

CD79B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

Identifiers

CD79B, AGM6, B29, IGB, CD79b molecule, Igbeta

External IDs

OMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs

Gene location (Human)

Chromosome 17 (human)^[1]

17q23.3

Start

63,928,740 bp^[1]

End

63,932,336 bp^[1]

Gene location (Mouse)

Chromosome 11 (mouse)^[2]

11 E1|11 68.89 cM

Start

106,202,167 bp^[2]

End

106,205,588 bp^[2]

RNA expression pattern

Mouse (ortholog)

Top expressed in

granulocyte

spleen

lymph node

appendix

apex of heart

blood

monocyte

gonad

bone marrow

anterior pituitary

Top expressed in

mesenteric lymph nodes

spleen

tibiofemoral joint

blood

bone marrow

granulocyte

submandibular gland

thymus

subcutaneous adipose tissue

tunica adventitia of aorta

More reference expression data

More reference expression data

Molecular function

protein binding

transmembrane signaling receptor activity

protein homodimerization activity

identical protein binding

Cellular component

integral component of membrane

plasma membrane

Golgi apparatus

integral component of plasma membrane

extracellular exosome

external side of plasma membrane

B cell receptor complex

Biological process

cell surface receptor signaling pathway

adaptive immune response

immune response

signal transduction

immune system process

B cell differentiation

B cell receptor signaling pathway

protein homooligomerization

response to bacterium

Sources:Amigo / QuickGO

Species

Human

Mouse

ENSG00000007312

ENSMUSG00000040592

RefSeq (mRNA)

NM_000626
NM_001039933
NM_021602
NM_001329050

NM_008339
NM_001313939

RefSeq (protein)

NP_000617
NP_001035022
NP_001315979
NP_067613

NP_001300868
NP_032365

Location (UCSC)

Chr 17: 63.93 – 63.93 Mb

Chr 11: 106.2 – 106.21 Mb

PubMed search

View/Edit Human

View/Edit Mouse

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[5]

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

See also[edit]

Cluster of differentiation

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

Further reading[edit]

Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.

Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761. S2CID 23910309.

Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031. S2CID 25093082.

Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.

Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. doi:10.1016/S0021-9258(17)32545-0. PMID 7516335.

Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.

Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMC 2192043. PMID 7539038.

Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.

Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.

Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.

Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081. S2CID 6966566.

Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. doi:10.4049/jimmunol.153.6.2369. PMID 8077654. S2CID 22158525.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. doi:10.4049/jimmunol.150.2.491. PMID 8419481. S2CID 36149482.

Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.

Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression". Blood. 87 (2): 666–73. doi:10.1182/blood.V87.2.666.bloodjournal872666. PMID 8555489.

Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID 8656670.

Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.

Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. doi:10.4049/jimmunol.158.7.3062. PMID 9120258. S2CID 20717278.

External links[edit]

CD79B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD79B genome location and CD79B gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1–50

CD1
- a-c

γ
δ
ε

a

CD11

a
b
c
d

A
B

A
B

a
b
c
d

CD49

a
b
c
d
e
f

51–100

CD51

E
L
P

A
B
C

a
b
c
d
e
f

a
b

CD85

a
d
e
h
j
k

101–150

CD101

CD107

a
b

a
b

CD121

a
b

151–200

CD151

CD156

a
b
c

CD158 (a

d

e

i

k)

CD159

a
c

CD167

a
b

CD172

a
b
g

CD179

a
b

201–250

CD201

CDw210

a
b

CD213a

1
2

CD218 (a

b)

CD235

a
b

251–300

CD252

301–350

CD300A

Transmembrane receptors: immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

FcεRI

(FcεRIIisC-type lectin)

FcγRI

Alpha (α)/mu (μ)

FcαRI

Secretory

Polymeric immunoglobulin receptor

Antigen receptor

Antigen receptor

BCR

stimulate:

CD21/CD19/CD81

inhibit:

CD22

Accessory molecules

Ig-α/Ig-β (CD79)

MHC
- MHC class I

Antigen receptor

TCR: TRA@

CD8 (with two glycoprotein chains CD8α and CD8β)

Accessory molecules

CD3

ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor

see cytokine receptors

Killer-cell IG-like receptors

KIR2DL1

Leukocyte IG-like receptors

LILRA1

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

t

e

Retrieved from "https://en.wikipedia.org/w/index.php?title=CD79B&oldid=1170123595" Categories: ●Genes on human chromosome 17 ●Clusters of differentiation ●Membrane protein stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●Wikipedia articles incorporating text from the United States National Library of Medicine ●All stub articles ●This page was last edited on 13 August 2023, at 08:39 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view