RHAG
Identifiers
RHAG, CD241, RH2, RH50A, Rh50, Rh50GP, SLC42A1, OHS, OHST, Rh-associated glycoprotein, Rh associated glycoprotein, RHNR
External IDs
OMIM: 180297; MGI: 1202713; HomoloGene: 68045; GeneCards: RHAG; OMA:RHAG - orthologs
Gene location (Human)
6p12.3
Start
End
Gene location (Mouse)
Chromosome 17 (mouse)[2]
17 B2|17 19.54 cM
Start
End
Molecular function
Cellular component
Biological process
Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Rh-associated glycoprotein (RHAG) is an ammonia transporter protein that in humans is encoded by the RHAG gene.[5][6] RHAG has also recently been designated CD241 (cluster of differentiation 241). Mutations in the RHAG gene can cause stomatocytosis.[7]
The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein [supplied by OMIM].[6]
RHAG has been shown to interact with ANK1.[8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
General concepts
Methods
Tests
Transfusion reactions
and adverse effects
1–50
51–100
101–150
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201–250
251–300
301–350
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see also solute carrier disorders
