JAM2
Identifiers
JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2, IBGC8
External IDs
OMIM: 606870; MGI: 1933820; HomoloGene: 10929; GeneCards: JAM2; OMA:JAM2 - orthologs
Gene location (Human)
21q21.3
Start
End
Gene location (Mouse)
Chromosome 16 (mouse)[2]
16|16 C3.3
Start
End
Cellular component
Biological process
Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[5][6][7] JAM2 has also been designated as CD322 (cluster of differentiation 322).
Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[7]
It is purported to promote lymphocyte transendothelial migration.[8] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.[9]
JAM2 has been shown to interact with PARD3.[9]
It also interacts with the integrin dimer VLA-4 (also called α4β1).[10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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