cholest-5-ene-3β,7α-diol 3β-dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.181 | ||||||||
CAS no. | 56626-16-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 | |||||||
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Identifiers | |||||||
Symbol | HSD3B7 | ||||||
NCBI gene | 80270 | ||||||
HGNC | 18324 | ||||||
OMIM | 607764 | ||||||
RefSeq | NM_025193 | ||||||
UniProt | Q9H2F3 | ||||||
Other data | |||||||
EC number | 1.1.1.181 | ||||||
Locus | Chr. 16 p11.2 | ||||||
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Inenzymology, a cholest-5-ene-3β,7α-diol 3β-dehydrogenase (EC 1.1.1.181) is an enzyme that catalyzes the chemical reaction[1]
Thus, the two substrates of this enzyme are cholest-5-ene-3β,7α-diol and NAD+, whereas its 3 products are 7α-hydroxycholest-4-en-3-one, NADH, and H+.
The systematic name of this enzyme class is cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3β-hydroxy-Δ5-C27-steroid oxidoreductase. The human version of this enzyme is known as hydroxy-Δ-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 7orHSD3B7 which is encoded by the HSD3B7 gene.[2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. This enzyme is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates.[4]
Mutations in the HSD3B7 gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease.[4]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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