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(Top) 1 Interactions 2 See also 3 References 4 Further reading 5 External links

DNA polymerase alpha subunit 2

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POLA2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2KEB, 4E2I, 4Y97, 5EXR

Identifiers

Aliases

POLA2, DNA polymerase alpha 2, accessory subunit

External IDs

MGI: 99690; HomoloGene: 48121; GeneCards: POLA2; OMA:POLA2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.1	Start	65,261,920 bp^[1]
Band	11q13.1	End	65,305,589 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	5,990,570 bp^[2]
Band	19\|19 A	End	6,014,230 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

embryo

gonad

ganglionic eminence

mucosa of transverse colon

apex of heart

bone marrow cells

spleen

canal of the cervix

granulocyte

Top expressed in

tail of embryo

genital tubercle

epiblast

spermatocyte

yolk sac

somite

pharynx

maxillary prominence

mandibular prominence

thymus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding DNA-directed DNA polymerase activity protein heterodimerization activity molecular function
Cellular component	alpha DNA polymerase:primase complex nucleus nucleoplasm cytosol
Biological process	DNA replication DNA biosynthetic process DNA replication initiation telomere maintenance via semi-conservative replication G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23649


18969

Ensembl


ENSG00000014138


ENSMUSG00000024833

UniProt


Q14181


P33611

RefSeq (mRNA)


NM_002689


NM_001164057 NM_008893

RefSeq (protein)


NP_002680


NP_001157529 NP_032919

Location (UCSC)

Chr 11: 65.26 – 65.31 Mb

Chr 19: 5.99 – 6.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.^[5]^[6]^[7]

Interactions[edit]

POLA2 has been shown to interact with PARP1.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000014138 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024833 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Collins KL, Russo AA, Tseng BY, Kelly TJ (Dec 1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J. 12 (12): 4555–66. doi:10.1002/j.1460-2075.1993.tb06144.x. PMC 413886. PMID 8223465.

^ Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.

^ "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".

^ Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (Apr 1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.

Further reading[edit]

Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer HP (2003). "Regulation of eukaryotic DNA replication at the initiation step". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/BST0310266. PMID 12546699.

Nasheuer HP, Moore A, Wahl AF, Wang TS (1991). "Cell cycle-dependent phosphorylation of human DNA polymerase alpha". J. Biol. Chem. 266 (12): 7893–903. doi:10.1016/S0021-9258(20)89534-9. PMID 1902230.

Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.

Schneider A, Smith RW, Kautz AR, Weisshart K, Grosse F, Nasheuer HP (1998). "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit". J. Biol. Chem. 273 (34): 21608–15. doi:10.1074/jbc.273.34.21608. PMID 9705292.

Taneja P, Gu J, Peng R, Carrick R, Uchiumi F, Ott RD, Gustafson E, Podust VN, Fanning E (2002). "A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication". J. Biol. Chem. 277 (43): 40853–61. doi:10.1074/jbc.M208067200. PMID 12181327.

Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.