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(Top) 1 References 2 Further reading

POLD4

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POLD4

Identifiers

Aliases

POLD4, POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit

External IDs

OMIM: 611525; MGI: 1916995; HomoloGene: 10909; GeneCards: POLD4; OMA:POLD4 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	67,350,772 bp^[1]
Band	11q13.2	End	67,356,972 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	4,281,953 bp^[2]
Band	19\|19 A	End	4,283,688 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

right lobe of liver

granulocyte

duodenum

appendix

lymph node

Descending thoracic aorta

blood

left coronary artery

right coronary artery

Top expressed in

spleen

white adipose tissue

urinary bladder

granulocyte

adrenal gland

bone marrow

pancreas

islet of Langerhans

lip

muscle of thigh

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding DNA-directed DNA polymerase activity
Cellular component	delta DNA polymerase complex nucleoplasm nucleolus mitochondrion cytosol nucleus
Biological process	DNA-dependent DNA replication nucleotide-excision repair, DNA gap filling DNA synthesis involved in DNA repair translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision telomere maintenance nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA replication DNA mismatch repair
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57804


69745

Ensembl


ENSG00000175482


ENSMUSG00000024854

UniProt


Q9HCU8


Q9CWP8

RefSeq (mRNA)


NM_001256870 NM_021173


NM_027196

RefSeq (protein)


NP_001243799 NP_066996


NP_081472

Location (UCSC)

Chr 11: 67.35 – 67.36 Mb

Chr 19: 4.28 – 4.28 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene.^[5] It is a component of the DNA polymerase delta complex.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175482 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024854 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: polymerase (DNA-directed)".

Further reading[edit]

Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme". Biochemistry. 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614.

Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta". Nucleic Acids Res. 36 (16): 5166–79. doi:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.

Bae SH, Bae KH, Kim JA, Seo YS (2001). "RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes". Nature. 412 (6845): 456–61. doi:10.1038/35086609. PMID 11473323. S2CID 4337704.

Matsumoto Y, Kim K, Hurwitz J, et al. (1999). "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins". J. Biol. Chem. 274 (47): 33703–8. doi:10.1074/jbc.274.47.33703. PMID 10559261.

Liu G, Warbrick E (2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.

Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.

Wood RD, Shivji MK (1997). "Which DNA polymerases are used for DNA-repair in eukaryotes?". Carcinogenesis. 18 (4): 605–10. doi:10.1093/carcin/18.4.605. PMID 9111189.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Huang QM, Akashi T, Masuda Y, et al. (2010). "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells". Biochem. Biophys. Res. Commun. 391 (1): 542–6. doi:10.1016/j.bbrc.2009.11.094. PMID 19931513.

Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.

Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). "Identification of a fourth subunit of mammalian DNA polymerase delta". J. Biol. Chem. 275 (25): 18739–44. doi:10.1074/jbc.M001217200. PMID 10751307.