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dnaN

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DNA polymerase III subunit beta

Crystallographic structure of the dimeric DNA polymerase beta subunit from E. coli.^[1]

Identifiers

Organism

Escherichia coli
(str. K-12 substr. MG1655)

Symbol

dnaN

Other data

MG1655: 3.88 - 3.88 Mb

Search for
Structures	Swiss-model
Domains	InterPro

dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes.^[2]^[3] The β clamp physically locks Pol III onto a DNA strand during replication to help increase its processivity.^[4] The eukaryotic equivalent to the β clamp is PCNA.

References[edit]

^ PDB: 1MMI; Oakley AJ, Prosselkov P, Wijffels G, Beck JL, Wilce MC, Dixon NE (July 2003). "Flexibility revealed by the 1.85 Å crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III" (PDF). Acta Crystallogr. D. 59 (Pt 7): 1192–9. doi:10.1107/S0907444903009958. PMID 12832762.

^ Ohmori H, Kimura M, Nagata T, Sakakibara Y (May 1984). "Structural analysis of the dnaA and dnaN genes of Escherichia coli". Gene. 28 (2): 159–70. doi:10.1016/0378-1119(84)90253-1. PMID 6234204.

^ Armengod ME, García-Sogo M, Lambíes E (August 1988). "Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12". J. Biol. Chem. 263 (24): 12109–14. PMID 2841344.

^ Stukenberg PT, Studwell-Vaughan PS, O'Donnell M (June 1991). "Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme". J. Biol. Chem. 266 (17): 11328–34. PMID 2040637.